pentobarbital will minimize the extent or effect of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or influence of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers decreases plas